Bourgonje Julius Z.
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Introduction : Crohn's disease CD is characterized by chronic and relapsing inflammation of the gastro-intestinal tract. It is assumed that oxidative stress contributes to CD pathogenesis, but systemic biomarkers for oxidative stress in CD are not yet identified.
A reduction in free thiol groups in plasma proteins ''plasma free thiols'' reflects systemic oxidative stress since they are prime substrates for reactive oxygen species. Here, we determined the concentrations of plasma free thiols in CD patients and healthy controls and studied the putative correlation with disease parameters.
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Methods : Free thiols were quantified in plasma of patients with CD in clinical remission according to the Harvey Bradshaw Index HBI and healthy controls and adjusted for plasma albumin. Albumin-adjusted free thiol concentrations were analyzed for associations with clinical and biochemical disease markers.
Patients with CD having solely colonic disease demonstrated markedly reduced plasma free thiol concentrations compared to patients with ileocolonic involvement Conclusion : Plasma free thiols are reduced in patients with CD in clinical remission compared to healthy controls. In achieving this award, Brompton have demonstrated continued commitment to empowering and engaging people, supporting a company-wide culture of learning and creating a high-performance environment that delivers the ultimate value to all our customers.
Commenting on the award, Michelle Nolan, Head of HR and Education Support said: "We are delighted to have been accredited Investors in People; it demonstrates our ambition to invest in our people to achieve our goals, create a culture of empowerment, recognition and reward, and invest time in learning and development.
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